Sandbox c12



1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

attached to the Fe

Tacrines ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330 )